Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

Bell, I M; Gallicchio, S N; Abrams, M; Beshore, D C; Buser, C A; Culberson, J C; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, J B; Graham, S L; Hartman, G D; Heimbrook, D C; Homnick, C F; Huff, J R; Kassahun, K; Koblan, K S; Kohl, N E; Lobell, R B; Lynch, J J; Miller, P A; Omer, C A; Rodrigues, A D; Walsh, E S; Williams, T M

Bell, I M; Gallicchio, S N; Abrams, M; Beshore, D C; Buser, C A; Culberson, J C; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, J B; Graham, S L; Hartman, G D; Heimbrook, D C; Homnick, C F; Huff, J R; Kassahun, K; Koblan, K S; Kohl, N E; Lobell, R B; Lynch, J J; Miller, P A; Omer, C A; Rodrigues, A D; Walsh, E S; Williams, T M.

Affiliation

Bell IM; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. ian_bell@merck.com

J Med Chem ; 44(18): 2933-49, 2001 Aug 30.

Article in En | MEDLINE | ID: mdl-11520202

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidinones / Alkyl and Aryl Transferases / Enzyme Inhibitors / Imidazoles / Lactams / Antineoplastic Agents / Nitriles Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2001 Document type: Article Affiliation country: Country of publication:

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