Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.
Cell Biol Toxicol
; 18(2): 87-96, 2002.
Article
in En
| MEDLINE
| ID: mdl-12046693
ABSTRACT
Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, including lung, brain, melanoma, liver, prostate, breast, and renal cancers, Cap43 protein is overexpressed in cancer cells. The low level of expression of Cap43 in some normal tissues compared to their cancerous counterparts combined with the high stability of Cap43 protein and mRNA makes the Cap43 gene a new, important cancer marker. We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Neoplasm Proteins
/
Neoplasms
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Cell Biol Toxicol
Journal subject:
TOXICOLOGIA
Year:
2002
Document type:
Article
Affiliation country: