Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).

Wissner, Allan; Overbeek, Elsebe; Reich, Marvin F; Floyd, M Brawner; Johnson, Bernard D; Mamuya, Nellie; Rosfjord, Edward C; Discafani, Carolyn; Davis, Rachel; Shi, Xiaoqing; Rabindran, Sridhar K; Gruber, Brian C; Ye, Fei; Hallett, William A; Nilakantan, Ramaswamy; Shen, Ru; Wang, Yu-Fen; Greenberger, Lee M; Tsou, Hwei-Ru

Wissner, Allan; Overbeek, Elsebe; Reich, Marvin F; Floyd, M Brawner; Johnson, Bernard D; Mamuya, Nellie; Rosfjord, Edward C; Discafani, Carolyn; Davis, Rachel; Shi, Xiaoqing; Rabindran, Sridhar K; Gruber, Brian C; Ye, Fei; Hallett, William A; Nilakantan, Ramaswamy; Shen, Ru; Wang, Yu-Fen; Greenberger, Lee M; Tsou, Hwei-Ru.

Affiliation

Wissner A; Chemical Sciences, Oncology and Immunoinflammatory Research, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. wissnea@wyeth.com

J Med Chem ; 46(1): 49-63, 2003 Jan 02.

Article in En | MEDLINE | ID: mdl-12502359

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Collection: 01-internacional Database: MEDLINE Main subject: Organic Chemicals / Receptor, ErbB-2 / Enzyme Inhibitors / ErbB Receptors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Document type: Article Affiliation country: Country of publication:

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