Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.

Aranapakam, Venkatesan; Davis, Jamie M; Grosu, George T; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I; Sandanayaka, Vincent P; Du, Mila; Skotnicki, Jerauld S; DiJoseph, John F; Sung, Amy; Sharr, Michele A; Killar, Loran M; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao

Aranapakam, Venkatesan; Davis, Jamie M; Grosu, George T; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I; Sandanayaka, Vincent P; Du, Mila; Skotnicki, Jerauld S; DiJoseph, John F; Sung, Amy; Sharr, Michele A; Killar, Loran M; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao.

Affiliation

Aranapakam V; Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. venkata@wyeth.com

J Med Chem ; 46(12): 2376-96, 2003 Jun 05.

Article in En | MEDLINE | ID: mdl-12773042

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Piperidines / Protease Inhibitors / Sulfones / Matrix Metalloproteinase Inhibitors / Hydroxamic Acids Type of study: Prognostic_studies Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Document type: Article Affiliation country: Country of publication:

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