Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
Ann Neurol
; 54(1): 119-22, 2003 Jul.
Article
in En
| MEDLINE
| ID: mdl-12838528
ABSTRACT
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54119-122
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antigens, Differentiation
/
HLA-DR Antigens
/
Immunoconjugates
/
Multiple Sclerosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Ann Neurol
Year:
2003
Document type:
Article
Affiliation country: