Diagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstruction.
Gastroenterol Clin North Am
; 32(2): 619-58, 2003 Jun.
Article
in En
| MEDLINE
| ID: mdl-12858609
Chronic gastroparesis and CIP are debilitating disorders that are difficult to treat with currently available therapies. Failure of proper migration and differentiation of enteric neurons or ICC can result from specific genetic mutations and lead to phenotypes of CIP with or without concomitant gastroparesis. Intestinal dysfunction in diabetes may reflect a depletion of NO production (and perhaps other neurotransmitters or modulators), which is manifest as a syndrome of gastroparesis, diarrhea, or constipation in individual patients. As the key molecular changes underlying these disorders are defined, clinicians will begin to understand their precise etiology and rational medical therapy may become possible. In the future, testable hypotheses regarding the etiology of other functional bowel disorders (e.g., functional dyspepsia, irritable bowel syndrome, and so forth) may be developed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Intestinal Pseudo-Obstruction
/
Gastroparesis
Type of study:
Diagnostic_studies
Limits:
Adult
/
Child
/
Humans
Language:
En
Journal:
Gastroenterol Clin North Am
Journal subject:
GASTROENTEROLOGIA
Year:
2003
Document type:
Article
Affiliation country:
Country of publication: