Cryptosporidiosis in HIV-seropositive patients.
Q J Med
; 85(307-308): 813-23, 1992.
Article
in En
| MEDLINE
| ID: mdl-1362461
The incidence of cryptosporidiosis in our unit has increased over the last 6 years, being diagnosed in approximately 5 per cent of all patients with HIV infection and in 21 per cent of those with AIDS, but a marked seasonal variation occurs. We have studied the course of the infection in 128 patients and identified four clinical patterns of disease: transient (28.7 per cent), chronic (59.7 per cent), fulminant (7.8 per cent) and asymptomatic (3.9 per cent). Transient disease occurred in patients with a wide range of CD4 lymphocyte counts, but was more common in less immunosuppressed patients. Fulminant disease, defined by the passage of more than 2 l of stool/day from the time of presentation, only occurred in patients with a CD4 count less than 50/mm3. This group had lost more than 7 kg in weight at presentation and more commonly had other intercurrent gastrointestinal infections. They survived for a median of only 5 weeks, compared with 20 weeks for those with chronic diarrhoea and 36 weeks for those with transient infection. The survival was unaffected by any treatment other than zidovudine. Cryptosporidiosis in HIV-infected individuals is a heterogeneous disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Seropositivity
/
AIDS-Related Opportunistic Infections
/
Cryptosporidiosis
Limits:
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Q J Med
Year:
1992
Document type:
Article
Country of publication: