PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseria meningitidis.
Antimicrob Agents Chemother
; 47(10): 3336-8, 2003 Oct.
Article
in En
| MEDLINE
| ID: mdl-14506052
ABSTRACT
We identified a previously undocumented mutation in the dihydropteroate synthase (folP) gene associated with Neisseria meningitidis sulfonamide resistance. A PCR-based assay to detect this mutation, which is 100% predictive of sulfonamide resistance, was developed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfonamides
/
DNA Restriction Enzymes
/
Dihydropteroate Synthase
/
Mutation
/
Neisseria meningitidis
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2003
Document type:
Article
Affiliation country: