Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.

Guertin, Kevin R; Setti, Lina; Qi, Lida; Dunsdon, Rachel M; Dymock, Brian W; Jones, Philip S; Overton, Hilary; Taylor, Mathew; Williams, Glyn; Sergi, Joseph A; Wang, Karen; Peng, Ying; Renzetti, Marcia; Boyce, Rogely; Falcioni, Fiorenza; Garippa, Ralph; Olivier, Andrée R

Guertin, Kevin R; Setti, Lina; Qi, Lida; Dunsdon, Rachel M; Dymock, Brian W; Jones, Philip S; Overton, Hilary; Taylor, Mathew; Williams, Glyn; Sergi, Joseph A; Wang, Karen; Peng, Ying; Renzetti, Marcia; Boyce, Rogely; Falcioni, Fiorenza; Garippa, Ralph; Olivier, Andrée R.

Affiliation

Guertin KR; Roche Research Center, Hoffmann-LaRoche Inc., Nutley, NJ 07110, USA. kevin.guertin@roche.com

Bioorg Med Chem Lett ; 13(17): 2895-8, 2003 Sep 01.

Article in En | MEDLINE | ID: mdl-14611852

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Collection: 01-internacional Database: MEDLINE Main subject: Triazines / Protein Tyrosine Phosphatases / Diamines / Enzyme Inhibitors / Hypoglycemic Agents Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: Country of publication:

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