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Design and synthesis of benzofused heterocyclic RXR modulators.
Gernert, D L; Neel, D A; Boehm, M F; Leibowitz, M D; Mais, D A; Michellys, P Y; Rungta, D; Reifel-Miller, A; Grese, T A.
Affiliation
  • Gernert DL; Discovery Chemistry Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA. dgernert@lilly.com
Bioorg Med Chem Lett ; 14(11): 2759-63, 2004 Jun 07.
Article in En | MEDLINE | ID: mdl-15125928
Benzofused heterocyclic analogs of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the choice of heterocycle as well as the sidechain employed.
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Collection: 01-internacional Database: MEDLINE Main subject: Retinoid X Receptors / Heterocyclic Compounds, 3-Ring Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Retinoid X Receptors / Heterocyclic Compounds, 3-Ring Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Document type: Article Affiliation country: Country of publication: