Characterization of group B streptococci recovered from infants with invasive disease in England and Wales.
Clin Infect Dis
; 38(9): 1203-8, 2004 May 01.
Article
in En
| MEDLINE
| ID: mdl-15127328
ABSTRACT
Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes III (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype III strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Streptococcal Infections
/
Streptococcus agalactiae
Limits:
Humans
/
Infant
Country/Region as subject:
Europa
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2004
Document type:
Article
Affiliation country: