Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection.
Rev Inst Med Trop Sao Paulo
; 46(4): 231-3, 2004.
Article
in En
| MEDLINE
| ID: mdl-15361976
ABSTRACT
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24 h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Praziquantel
/
Schistosoma mansoni
/
Anthelmintics
Limits:
Animals
Language:
En
Journal:
Rev Inst Med Trop Sao Paulo
Year:
2004
Document type:
Article
Affiliation country: