Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.
Circulation
; 110(13): 1847-54, 2004 Sep 28.
Article
in En
| MEDLINE
| ID: mdl-15381647
ABSTRACT
BACKGROUND:
Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. METHODS ANDRESULTS:
Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.CONCLUSIONS:
G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hematopoietic Stem Cells
/
Granulocyte Colony-Stimulating Factor
/
Hematopoietic Stem Cell Mobilization
/
Infarction, Middle Cerebral Artery
Limits:
Animals
Language:
En
Journal:
Circulation
Year:
2004
Document type:
Article
Affiliation country: