Evaluation of two pairs of chiral stationary phases: effects from the length of the achiral spacers.
Chirality
; 16(9): 614-24, 2004 Nov.
Article
in En
| MEDLINE
| ID: mdl-15390085
ABSTRACT
Two pairs of chiral stationary phases (CSPs) with different C(2)-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chirality
Journal subject:
BIOLOGIA MOLECULAR
/
QUIMICA
Year:
2004
Document type:
Article
Affiliation country: