Immunoglobulin M myeloma: evaluation of molecular features and cytokine expression.
Clin Lymphoma
; 5(4): 285-9, 2005 Mar.
Article
in En
| MEDLINE
| ID: mdl-15794867
ABSTRACT
Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from WM. These cells are postgerminal-center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and MM. Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin M
/
Waldenstrom Macroglobulinemia
/
Multiple Myeloma
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Lymphoma
Journal subject:
NEOPLASIAS
Year:
2005
Document type:
Article
Affiliation country: