Transporting silence: design of carriers for siRNA to angiogenic endothelium.
J Control Release
; 109(1-3): 5-14, 2005 Dec 05.
Article
in En
| MEDLINE
| ID: mdl-15979191
ABSTRACT
The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several hurdles must be overcome including rapid clearance, nuclease degradation, and inefficient intracellular localization. In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Angiogenesis Inhibitors
/
RNA, Small Interfering
/
Neovascularization, Pathologic
Limits:
Animals
/
Humans
Language:
En
Journal:
J Control Release
Journal subject:
FARMACOLOGIA
Year:
2005
Document type:
Article
Affiliation country:
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS