Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery.
Anat Rec A Discov Mol Cell Evol Biol
; 287(2): 1165-75, 2005 Dec.
Article
in En
| MEDLINE
| ID: mdl-16302230
ABSTRACT
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Gene Expression Regulation, Developmental
/
Mesentery
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Anat Rec A Discov Mol Cell Evol Biol
Journal subject:
ANATOMIA
/
BIOLOGIA
/
BIOLOGIA MOLECULAR
Year:
2005
Document type:
Article
Affiliation country: