Assisted reproductive therapies and imprinting disorders--a preliminary British survey.
Hum Reprod
; 21(4): 1009-11, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16361294
ABSTRACT
BACKGROUND:
Recent reports have suggested a higher risk of Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) after assisted reproductive technologies (ARTs), but it is unclear whether this might also apply to other disorders of genomic imprinting.METHODS:
We contacted families of children with BWS, AS, Prader-Willi syndrome (PWS) and transient neonatal diabetes mellitus (TNDM) to determine use of ART.RESULTS:
A statistically significant increased frequency of ART in children with BWS was confirmed [2.9%, 95% confidence interval (CI) 1.4-6.3% vs 0.8% expected] but there was no significant association with PWS or TNDM. Consideration of the molecular subgroup of BWS and AS suggested the feasibility of association with ART.CONCLUSIONS:
These differences may relate to variations in (i) the molecular mechanisms for disordered imprinting in the different disorders and (ii) the susceptibility of specific imprinting control regions to ART-associated methylation alterations (epimutations).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genomic Imprinting
/
Chromosome Disorders
/
Reproductive Techniques, Assisted
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Hum Reprod
Journal subject:
MEDICINA REPRODUTIVA
Year:
2006
Document type:
Article
Affiliation country: