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8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor.
Humphries, Alexander C; Gancia, Emanuela; Gilligan, Myra T; Goodacre, Simon; Hallett, David; Merchant, Kevin J; Thomas, Steve R.
Affiliation
  • Humphries AC; The Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Harlow, Essex CM20 2QR, UK. alexander_humphries@merck.com
Bioorg Med Chem Lett ; 16(6): 1518-22, 2006 Mar 15.
Article in En | MEDLINE | ID: mdl-16386901
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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / GABA Agonists / Allosteric Regulation / GABA-A Receptor Agonists / Imidazoles Type of study: Evaluation_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Country of publication:
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / GABA Agonists / Allosteric Regulation / GABA-A Receptor Agonists / Imidazoles Type of study: Evaluation_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Country of publication: