Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.

McKew, John C; Foley, Megan A; Thakker, Paresh; Behnke, Mark L; Lovering, Frank E; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W H; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D

McKew, John C; Foley, Megan A; Thakker, Paresh; Behnke, Mark L; Lovering, Frank E; Sum, Fuk-Wah; Tam, Steve; Wu, Kun; Shen, Marina W H; Zhang, Wen; Gonzalez, Mario; Liu, Shanghao; Mahadevan, Anu; Sard, Howard; Khor, Soo Peang; Clark, James D.

Affiliation

McKew JC; Department of Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA. jmckew@wyeth.com

J Med Chem ; 49(1): 135-58, 2006 Jan 12.

Article in En | MEDLINE | ID: mdl-16392799

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Drug Design / Enzyme Inhibitors / Indoles Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: Country of publication:

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