Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization.
Org Lett
; 8(26): 5919-22, 2006 Dec 21.
Article
in En
| MEDLINE
| ID: mdl-17165894
ABSTRACT
[Structure see text] A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluoroacetates
/
Indoles
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2006
Document type:
Article