Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Nat Genet
; 39(7): 839-47, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17572675
ABSTRACT
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmaniasis
/
Genome
/
Genomics
/
Leishmania
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
2007
Document type:
Article
Affiliation country: