1H MRS spectroscopy evidence of cerebellar high lactate in mitochondrial respiratory chain deficiency.
Mol Genet Metab
; 93(1): 85-8, 2008 Jan.
Article
in En
| MEDLINE
| ID: mdl-17950645
ABSTRACT
Cerebellar ataxia is known to occasionally occur in the course of mitochondrial disorders. We report on MR spectroscopy (1H MRS) evidence of elevated brain lactate in the cerebellar area of 11 patients with cerebellar ataxia ascribed to mitochondrial respiratory chain deficiency (RCD). 1H MRS spectroscopy evidence of lactate peak was found in the cerebellum of 9/11 cases, while no lactate was detected in the putamen in 8/11. We suggest using 1H MRS in cerebellar atrophy in the diagnosis of mitochondrial RCD.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Spectroscopy
/
Cerebellum
/
Lactic Acid
/
Mitochondrial Diseases
Type of study:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Mol Genet Metab
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
METABOLISMO
Year:
2008
Document type:
Article
Affiliation country: