[Study on efficacy and safety of bioactive material--combest in treating burn].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
; 21(11): 1216-8, 2007 Nov.
Article
in Zh
| MEDLINE
| ID: mdl-18069479
ABSTRACT
OBJECTIVE:
To explore the efficacy and safety of bioactive material (combest) which is combinated with bioglass and hyaluronan on burn wound healing.METHODS:
From March to September 2006, 20 patients were treated; including 16 males and 4 females, aging 18-58 years(40 years on average). The wounds were classified as deep degrees II in 7 cases, granulated wounds in 9 cases and graft site wounds in 4 cases. Twenty wounds in one side were repaired with Combest as the test group and 20 wounds in the other side with blank cream as the control group. The wounds in size ranged from 2.0 cm x 1.5 cm to 40.0 cm x 20.0 cm. The wound healing rate was observed, and the blood test and the indices of hepatic and renal function were determined on the 1st, 3 rd, 6 th, 11 th, 16 th and 21 st days of treatment.RESULTS:
Wound healed within 3 weeks in 11 cases of the test group (3 cases on the 11 st day, 4 on the 16 th day, and 4 on the 21 st day) , but no wound healing was observed within 3 weeks in the control group. The healing size accounted for 2/3 of wounds in 18 cases of the test group and in 1 case of the control group. The excellent and good rates were 95%(18 cases and 1 case) in the test group and 50% (1 case and 9 cases) in the control group, showing significant difference (P<0.01). For all patients, no obvious changes were found in the blood test and hepatic or renal function indices.CONCLUSION:
Combest combinated with bioglass and hyaluronan is beneficial to the proliferation of the granulation and wound healing with good safety.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wound Healing
/
Biocompatible Materials
/
Burns
/
Foot Injuries
/
Forearm Injuries
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Year:
2007
Document type:
Article
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA