Your browser doesn't support javascript.
loading
Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.
Sebe, Attila; Masszi, András; Zulys, Matthew; Yeung, Tony; Speight, Pam; Rotstein, Ori D; Nakano, Hiroyasu; Mucsi, István; Szászi, Katalin; Kapus, András.
Affiliation
  • Sebe A; Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada.
FEBS Lett ; 582(2): 291-8, 2008 Jan 23.
Article in En | MEDLINE | ID: mdl-18154735
We investigated the mechanism whereby cell contact injury stimulates the alpha-smooth muscle actin (SMA) promoter, a key process for epithelial-mesenchymal transition (EMT) during organ fibrosis. Contact disruption by low-Ca(2+) medium (LCM) activated Rac, PAK and p38 MAPK, and triggered the nuclear accumulation of myocardin-related transcription factor (MRTF), an inducer of the SMA promoter. Dominant negative (DN) Rac, DN-PAK, DN-p38, or the p38 inhibitor SB203580 suppressed the LCM-induced nuclear accumulation of MRTF and the activation of the SMA promoter. These studies define novel pathway(s) involving Rac, PAK, and p38 in the regulation of MRTF and the contact-dependent induction of EMT.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Trans-Activators / Rac GTP-Binding Proteins / P38 Mitogen-Activated Protein Kinases / P21-Activated Kinases Limits: Animals Language: En Journal: FEBS Lett Year: 2008 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Trans-Activators / Rac GTP-Binding Proteins / P38 Mitogen-Activated Protein Kinases / P21-Activated Kinases Limits: Animals Language: En Journal: FEBS Lett Year: 2008 Document type: Article Affiliation country: Country of publication: