Surveillance and treatment of malignancy in Bloom syndrome.
Clin Oncol (R Coll Radiol)
; 20(5): 375-9, 2008 Jun.
Article
in En
| MEDLINE
| ID: mdl-18359209
ABSTRACT
We report a patient with Bloom syndrome, a rare autosomal recessive condition characterised by chromosomal instability leading to a high risk of cancer at an early age. The diagnosis should be considered in patients with any cancer of significantly early onset, short stature and a photosensitive lupus-like rash on the face. Diagnostic confirmation is obtained from chromosome studies that show significantly increased numbers of sister chromatid exchanges. There are important management implications, including minimising the use of ionising radiation in surveillance and treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bloom Syndrome
/
Neoplasms
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Clin Oncol (R Coll Radiol)
Journal subject:
NEOPLASIAS
Year:
2008
Document type:
Article
Affiliation country: