Local delivery of 17-beta-estradiol modulates collagen content in coronary porcine arteries after PTCA and stent implantation.
J Vasc Res
; 45(6): 503-11, 2008.
Article
in En
| MEDLINE
| ID: mdl-18451633
ABSTRACT
BACKGROUND:
Percutaneous transluminal coronary angioplasty (PTCA) and stent implantation are associated with intimal hyperplasia and extracellular matrix (ECM) accumulation, resulting in restenosis. We showed that local delivery of 17-beta-estradiol (17betaE) reduced restenosis following PTCA and stent implantation by 47 and 23%, respectively. Because estrogens decreased type I and type III collagen synthesis in vitro, we hypothesized that local delivery of 17betaE may influence intimal hyperplasia formation by modulating ECM expression.METHODS:
Porcine coronary arteries underwent PTCA or stenting and were randomly assigned to 17betaE or placebo. After 28 days, animals were sacrificed for histology and collagen type I and III content analysis.RESULTS:
Both collagen subtypes increased in the media by 1.7 to 2.6-fold after PTCA and by 15.7 to 16.1-fold after stenting, as compared to PTCA segments. In the neointima, the ratio of collagen type III to type I was 2.7 in stented arteries and only 0.3 in PTCA arteries. In the neointima of 17betaE-treated animals, collagen type I (but not type III) content upregulation was limited by 53% after PTCA and by 74% after stenting.CONCLUSION:
Local delivery of 17betaE reduces restenosis, in part by decreasing the density of collagen type I in the neointima in PTCA and stented arteries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Angioplasty, Balloon, Coronary
/
Stents
/
Coronary Vessels
/
Coronary Restenosis
/
Collagen Type I
/
Collagen Type III
/
Estradiol
Type of study:
Clinical_trials
/
Etiology_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
J Vasc Res
Journal subject:
ANGIOLOGIA
Year:
2008
Document type:
Article
Affiliation country: