Substituted dipiperidine alcohols as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 18(12): 3562-4, 2008 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-18487045
ABSTRACT
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperidines
/
Alcohols
/
Receptors, CCR2
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2008
Document type:
Article
Affiliation country: