Central lactate metabolism regulates food intake.
Am J Physiol Endocrinol Metab
; 295(2): E491-6, 2008 Aug.
Article
in En
| MEDLINE
| ID: mdl-18577696
ABSTRACT
The central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with the lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Lactic Acid
/
Eating
Limits:
Animals
Language:
En
Journal:
Am J Physiol Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Year:
2008
Document type:
Article
Affiliation country: