[Studies of betuionic acid on cell cycle and related protein expressions on mice of bearing H22 tumor cells].
Zhongguo Zhong Yao Za Zhi
; 33(14): 1739-43, 2008 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-18841782
ABSTRACT
OBJECTIVE:
To study the betulonic acid on the cell cycle and related protein expressions on mice of bearing H22 tumor cells.METHOD:
Flow cytometray was used to observe the changes of betulonic acid on the cell cycle and P53 of H22 tumor cells. Immunohistochemistry was determined the espressions of PI3K and AKT.RESULT:
Increasing the doses of betulonic acid, the number of H22 cells in S phase and G2 phase was increasing gradually, it can speculate that when the betulonic acid act on cells, the cells were blocked in S and G2 phase and inhibited the protein expressions of PI3K and AKT.CONCLUSION:
Betulonic acid may be up-regulate the activity of P53 and inhibite the expressions of PI3K and AKT, so that it inhibited the survival pathway of tumor cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
Cell Cycle
/
Gene Expression Regulation
/
Betula
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Journal subject:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Year:
2008
Document type:
Article
Affiliation country: