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Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Mayer, Scott C; Kreft, Anthony F; Harrison, Boyd; Abou-Gharbia, Magid; Antane, Madelene; Aschmies, Suzan; Atchison, Kevin; Chlenov, Michael; Cole, Derek C; Comery, Thomas; Diamantidis, George; Ellingboe, John; Fan, Kristi; Galante, Rocco; Gonzales, Cathleen; Ho, Douglas M; Hoke, Molly E; Hu, Yun; Huryn, Donna; Jain, Uday; Jin, Mei; Kremer, Kenneth; Kubrak, Dennis; Lin, Melissa; Lu, Peimin; Magolda, Ron; Martone, Robert; Moore, William; Oganesian, Aram; Pangalos, Menelas N; Porte, Alex; Reinhart, Peter; Resnick, Lynn; Riddell, David R; Sonnenberg-Reines, June; Stock, Joseph R; Sun, Shaiu-Ching; Wagner, Erik; Wang, Ting; Woller, Kevin; Xu, Zheng; Zaleska, Margaret M; Zeldis, Joseph; Zhang, Minsheng; Zhou, Hua; Jacobsen, J Steven.
Affiliation
  • Mayer SC; Chemical and Screening Sciences, and Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA. mayers@wyeth.com
J Med Chem ; 51(23): 7348-51, 2008 Dec 11.
Article in En | MEDLINE | ID: mdl-19012391
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiophenes / Enzyme Inhibitors / Receptor, Notch1 / Amyloid Precursor Protein Secretases / Drug Discovery / Alzheimer Disease Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiophenes / Enzyme Inhibitors / Receptor, Notch1 / Amyloid Precursor Protein Secretases / Drug Discovery / Alzheimer Disease Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication: