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Immunoglobulin M 'Flare' after rituximab-associated acute tubular necrosis in Waldenström's macroglobulinemia.
Izzedine, Hassane; Bourry, Edward; Amrouche, Lucile; Brocheriou, Isabelle; Uzunov, Madalina; Capron, Frederique; Leblond, Veronique; Deray, Gilbert.
Affiliation
  • Izzedine H; Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l'Hôpital, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, 75013, Paris, France. hassan.izzedine@psl.aphp.fr.
  • Bourry E; Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l'Hôpital, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, 75013, Paris, France.
  • Amrouche L; Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l'Hôpital, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, 75013, Paris, France.
  • Brocheriou I; Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.
  • Uzunov M; Department of Clinical Hematology, Pitie-Salpetriere Hospital, Paris, France.
  • Capron F; Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.
  • Leblond V; Department of Clinical Hematology, Pitie-Salpetriere Hospital, Paris, France.
  • Deray G; Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l'Hôpital, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, 75013, Paris, France.
Int J Hematol ; 89(2): 218-222, 2009 Mar.
Article in En | MEDLINE | ID: mdl-19156501
ABSTRACT
Waldenström's macroglobulinemia (WM) is a low-grade lymphoplasmacytic lymphoma characterized by a circulating monoclonal IgM. Renal involvement in classical cases of WM is rare, and the pathological hallmark finding in the renal biopsy specimen is a thrombotic microangiopathy. We report the case of a 69-year-old man with the diagnosis of WM for 3 months before he presented with acute renal failure (ARF). A renal biopsy performed suggested the diagnosis of acute tubular necrosis. The diagnosis of ARF related to IgM flare after Rituximab therapy was made.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin M / Waldenstrom Macroglobulinemia / Acute Kidney Injury / Kidney Tubules / Antibodies, Monoclonal Type of study: Risk_factors_studies Limits: Aged / Humans / Male Language: En Journal: Int J Hematol Journal subject: HEMATOLOGIA Year: 2009 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin M / Waldenstrom Macroglobulinemia / Acute Kidney Injury / Kidney Tubules / Antibodies, Monoclonal Type of study: Risk_factors_studies Limits: Aged / Humans / Male Language: En Journal: Int J Hematol Journal subject: HEMATOLOGIA Year: 2009 Document type: Article Affiliation country: