Late onset Pneumocystis pneumonia in renal transplantation after long-term immunosuppression with belatacept.
Transpl Infect Dis
; 11(2): 171-4, 2009 Apr.
Article
in En
| MEDLINE
| ID: mdl-19210692
ABSTRACT
Interference with T-cell function increases the risk of infections, especially during the early post-transplant period. Belatacept, a costimulation blocker, is currently being tested in phase III clinical trials. Here we report a renal transplant recipient who received belatacept and developed severe Pneumocystis jirovecii pneumonia (PCP) with fatal superinfections 4 years post transplant. Cytomegalovirus infection preceded PCP, which typically occurs in overimmunosuppressed patients, but has not yet been reported under T-cell costimulation blockade in transplant patients. This case illustrates the possibility of excessive immunosuppression even with a lymphocyte-specific regimen.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Pneumocystis
/
Postoperative Complications
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Superinfection
/
Kidney Transplantation
/
Immunoconjugates
/
Pneumocystis carinii
/
Immunosuppressive Agents
Type of study:
Diagnostic_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Transpl Infect Dis
Journal subject:
TRANSPLANTE
Year:
2009
Document type:
Article
Affiliation country: