Synthesis and biological evaluation of platensimycin analogs.
Bioorg Med Chem Lett
; 19(6): 1623-7, 2009 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-19233644
ABSTRACT
Platensimycin (1) displays antibacterial activity due to its inhibition of the elongation condensing enzyme (FabF), a novel mode of action that could potentially lead to a breakthrough in developing a new generation of antibiotics. The medicinal chemistry efforts were focused on the modification of the enone moiety of platensimycin and several analogs showed significant activity against FabF and possess antibacterial activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase
/
Bacterial Proteins
/
Adamantane
/
Chemistry, Pharmaceutical
/
Aminobenzoates
/
Anilides
/
Anti-Bacterial Agents
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2009
Document type:
Article
Affiliation country: