Favourable prognosis with modified dosing of docetaxel and cisplatin in Japanese patients with ovarian cancer.
Anticancer Res
; 29(2): 561-6, 2009 Feb.
Article
in En
| MEDLINE
| ID: mdl-19331203
ABSTRACT
BACKGROUND:
The long-term efficacy and safety of docetaxel/cisplatin as first-line chemotherapy in Japanese patients was evaluated in order to find an optional regimen for ovarian cancer. PATIENTS ANDMETHODS:
Women with surgically resected stage Ic-IV epithelial ovarian cancer were treated with docetaxel 70 mg/m2 and cisplatin 60 mg/m2 every 4 weeks.RESULTS:
Ninety women were enrolled of whom 89 (median age, 54 years) received a median of 6 cycles (range 1 to 9). With a median 38 months'follow-up, median progression-free survival was 28 months (95% lower confidence interval, 24 months) in 60 patients with stage III-IV disease. The overall response rate for 20 patients was 45%. Neutropenia was the most common (67%) grade 3/4 toxicity. Major grade 3/4 nonhaematological toxicities were gastrointestinal toxicities (< or = 11%) and fatigue (8%). No grade 3/4 neurotoxicity was observed.CONCLUSION:
The combination of docetaxel/cisplatin is a regimen with favourable progression-free survival for ovarian cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Anticancer Res
Year:
2009
Document type:
Article
Affiliation country:
Publication country:
GR
/
GRECIA
/
GREECE
/
GRÉCIA