Low molecular weight non-peptide mimics of omega-conotoxin GVIA.
Bioorg Med Chem Lett
; 19(10): 2763-5, 2009 May 15.
Article
in En
| MEDLINE
| ID: mdl-19362476
ABSTRACT
We report the synthesis and biological activity of a low molecular weight non-peptidic mimic of the analgesic peptide omega-conotoxin GVIA. The molecular weight of this compound presents a reduction by 193g/mol compared to a previously reported lead. This compound exhibits an EC(50) of 5.8microM and is accessible in only six synthetic steps compared to the original lead (13 steps). We also report several improvements to the original synthetic route.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Calcium Channel Blockers
/
Omega-Conotoxin GVIA
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2009
Document type:
Article
Affiliation country: