Bone turnover markers in the management of postmenopausal osteoporosis.
Clin Biochem
; 42(10-11): 929-42, 2009 Jul.
Article
in En
| MEDLINE
| ID: mdl-19362543
ABSTRACT
Osteoporosis is the most common cause of fragility fractures. Bone remodelling is essential for repairing damaged areas within bone to preserve bone strength and for assisting in mineral homeostases. In young adults, bone remodelling is usually balanced with approximately as much bone replaced as is removed during each remodelling cycle. However, when remodelling becomes accelerated in combination with an imbalance that favours bone resorption over formation, such as during menopause, precipitous losses in bone mass occur. Bone turnover markers (BTMs) measure the rate of bone remodelling allowing for a dynamic assessment of skeletal status and hold promise in identifying those at highest risk of rapid bone loss and subsequent fracture. Further, the use of BTMs to monitor individuals administered osteoporosis therapy is attractive as monitoring anti-fracture efficacy with bone mineral density has significant limitations. This review details remodelling biology, pre-analytical and analytical sources of variability for BTMs, describes the most commonly used resorption and formation markers, and offers some guidelines for their use and interpretation in the laboratory and the clinic.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis, Postmenopausal
/
Bone Remodeling
Type of study:
Guideline
Limits:
Female
/
Humans
Language:
En
Journal:
Clin Biochem
Year:
2009
Document type:
Article
Affiliation country: