The association between high VEGF levels and multiple probable punctuate cavernous malformations.
Acta Neurochir (Wien)
; 151(7): 855-9, 2009 Jul.
Article
in En
| MEDLINE
| ID: mdl-19479188
ABSTRACT
Cerebral cavernous malformations (CCMs) are congenital abnormalities of the cerebral vessels. The de novo development of new lesions in this disease has been reported. However, the underlying mechanism of progressive CCMs in such patients remains unclear. This report documents two cases of multiple probable CCMs that showed a progressive behaviour. The plasma levels of vascular endothelial growth factor (VEGF), and transforming growth factor-beta1 (TGF-beta1) were measured using an enzyme-linked immunosorbent assay (ELISA). The concentration of both VEGF and TGF-beta1 in plasma was increased in these patients. A relationship was observed between high concentrations of growth factors and progressive CCMs. Even though a causal linkage between these conditions cannot be confirmed, a continuous high VEGF level in plasma could be a possible clinical indicator for subsequent intracerebral haemorrhages in the CCM patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Hemorrhage
/
Hemangioma, Cavernous, Central Nervous System
/
Vascular Endothelial Growth Factor A
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Neurochir (Wien)
Year:
2009
Document type:
Article
Affiliation country: