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Pentazocine transport by square-wave AC iontophoresis with an adjusted duty cycle.
Ogami, Saori; Hayashi, Shizuka; Shibaji, Takao; Umino, Masahiro.
Affiliation
  • Ogami S; Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. saryanph@tmd.ac.jp
J Med Dent Sci ; 55(1): 15-27, 2008 Mar.
Article in En | MEDLINE | ID: mdl-19845146
So far, pentazocine iontophoresis has never been studied, although pentazocine is widely used in pain management. The purpose of this study was to determine whether pentazocine transportation through a cellophane membrane could be enhanced using square-wave alternating current (AC) iontophoresis with an adjusted duty cycle and dependence on the voltage and the duty cycle. Voltages of 10, 25 and 40 V with duty cycles of 50%, 51%, 52%, 53%, 54% and 55% were applied for 60 minutes at a high frequency of 1 MHz to diffusion cells on both sides of a cellophane membrane. The donor compartment was filled with a solution containing pentazocine. Square-wave AC iontophoresis with an adjusted duty cycle enhanced pentazocine transportation at higher voltages and duty cycles. These results suggested that the direct current (DC) component of the square-wave AC played an important role in enhancing pentazocine transportation despite changes in polarity at very high frequency of 1 MHz. The higher voltages and duty cycles induced a pH change. The practical electrical conditions that could be applied clinically were 25 V with a 54% duty cycle or 40 V with a 53% duty cycle.
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Collection: 01-internacional Database: MEDLINE Main subject: Pentazocine / Iontophoresis / Drug Delivery Systems / Analgesics, Opioid Language: En Journal: J Med Dent Sci Journal subject: MEDICINA / ODONTOLOGIA Year: 2008 Document type: Article Affiliation country: Country of publication:
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Collection: 01-internacional Database: MEDLINE Main subject: Pentazocine / Iontophoresis / Drug Delivery Systems / Analgesics, Opioid Language: En Journal: J Med Dent Sci Journal subject: MEDICINA / ODONTOLOGIA Year: 2008 Document type: Article Affiliation country: Country of publication: