Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.

Mackman, Richard L; Ray, Adrian S; Hui, Hon C; Zhang, Lijun; Birkus, Gabriel; Boojamra, Constantine G; Desai, Manoj C; Douglas, Janet L; Gao, Ying; Grant, Deborah; Laflamme, Genevieve; Lin, Kuei-Ying; Markevitch, David Y; Mishra, Ruchika; McDermott, Martin; Pakdaman, Rowchanak; Petrakovsky, Oleg V; Vela, Jennifer E; Cihlar, Tomas

Mackman, Richard L; Ray, Adrian S; Hui, Hon C; Zhang, Lijun; Birkus, Gabriel; Boojamra, Constantine G; Desai, Manoj C; Douglas, Janet L; Gao, Ying; Grant, Deborah; Laflamme, Genevieve; Lin, Kuei-Ying; Markevitch, David Y; Mishra, Ruchika; McDermott, Martin; Pakdaman, Rowchanak; Petrakovsky, Oleg V; Vela, Jennifer E; Cihlar, Tomas.

Affiliation

Mackman RL; Department of Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA94404, USA. Richard.Mackman@gilead.com

Bioorg Med Chem ; 18(10): 3606-17, 2010 May 15.

Article in En | MEDLINE | ID: mdl-20409721

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenine / HIV-1 / Reverse Transcriptase Inhibitors / Anti-HIV Agents / Guanosine Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: Country of publication:

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