Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.

Woodhead, Andrew J; Angove, Hayley; Carr, Maria G; Chessari, Gianni; Congreve, Miles; Coyle, Joseph E; Cosme, Jose; Graham, Brent; Day, Philip J; Downham, Robert; Fazal, Lynsey; Feltell, Ruth; Figueroa, Eva; Frederickson, Martyn; Lewis, Jonathan; McMenamin, Rachel; Murray, Christopher W; O'Brien, M Alistair; Parra, Lina; Patel, Sahil; Phillips, Theresa; Rees, David C; Rich, Sharna; Smith, Donna-Michelle; Trewartha, Gary; Vinkovic, Mladen; Williams, Brian; Woolford, Alison J-A

Woodhead, Andrew J; Angove, Hayley; Carr, Maria G; Chessari, Gianni; Congreve, Miles; Coyle, Joseph E; Cosme, Jose; Graham, Brent; Day, Philip J; Downham, Robert; Fazal, Lynsey; Feltell, Ruth; Figueroa, Eva; Frederickson, Martyn; Lewis, Jonathan; McMenamin, Rachel; Murray, Christopher W; O'Brien, M Alistair; Parra, Lina; Patel, Sahil; Phillips, Theresa; Rees, David C; Rich, Sharna; Smith, Donna-Michelle; Trewartha, Gary; Vinkovic, Mladen; Williams, Brian; Woolford, Alison J-A.

Affiliation

Woodhead AJ; Medicinal Chemistry, Astex Therapeutics, Ltd., Cambridge, UK. a.woodhead@astex-therapeutics.com

J Med Chem ; 53(16): 5956-69, 2010 Aug 26.

Article in En | MEDLINE | ID: mdl-20662534

Subject(s)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / HSP90 Heat-Shock Proteins / Isoindoles / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Country of publication:

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google