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Is quantitative diffusion-weighted MRI a reliable method in the assessment of the inflammatory activity in ulcerative colitis?
Kiliçkesmez, Ozgür; Soylu, Aliye; Yasar, Nurgül; Demirbas, Tuna; Dolapçioglu, Can; Poturoglu, Sule; Sevindir, Isa; Cimilli, Tan.
Affiliation
  • Kiliçkesmez O; Department of Radiology, Yeditepe University School of Medicine, Istanbul, Turkey. okilickesmez@yahoo.com
Diagn Interv Radiol ; 16(4): 293-8, 2010 Dec.
Article in En | MEDLINE | ID: mdl-20698008
PURPOSE: We investigated the relationship between the apparent diffusion coefficient (ADC) values of the colonic wall and the pathologic pericolonic lymph nodes (PCLNs) and inflammatory activity in ulcerative colitis patients by diffusion-weighted magnetic resonance imaging (DW-MRI). MATERIALS AND METHODS: A total of 28 ulcerative colitis patients (9 endoscopically active, 10 subacute and 9 in remission) were evaluated by DW-MRI with 0, 500 and 1000 s/mm² b-values. The ADC values of the rectum and sigmoid colon walls and the adjacent PCLNs were obtained for quantitative analysis. The DW-MRI findings were compared to the disease activity. RESULTS: The ADC values of the sigmoid colon were similar in patients with active, subacute and remissive ulcerative colitis (P = 0.472). The ADC values of the rectum were different (P = 0.009) between patients in the active (1.08 ± 0.14×10⁻³ mm²/s) and subacute phases (1.13 ± 0.23×10⁻³ mm²/s) of disease and those in remission (1.29 ± 0.17×10⁻³ mm²/s). The ADC values of the PCLNs (P = 0.899) did not differ with respect to disease activity. CONCLUSION: DW-MRI is useful in identifying disease activity in ulcerative colitis patients, especially with respect to the rectum. The ADC values of the rectum increase during remission and decrease in patients with active distal colitis. The ADC values of the PCLNs were not useful in determining disease activity.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Diffusion Magnetic Resonance Imaging / Inflammation Type of study: Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Diagn Interv Radiol Journal subject: DIAGNOSTICO POR IMAGEM / RADIOLOGIA Year: 2010 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Diffusion Magnetic Resonance Imaging / Inflammation Type of study: Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Diagn Interv Radiol Journal subject: DIAGNOSTICO POR IMAGEM / RADIOLOGIA Year: 2010 Document type: Article Affiliation country: Country of publication: