Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38&#945; MAP kinase inhibitors.

Lin, Shuqun; Wrobleski, Stephen T; Hynes, John; Pitt, Sidney; Zhang, Rosemary; Fan, Yi; Doweyko, Arthur M; Kish, Kevin F; Sack, John S; Malley, Mary F; Kiefer, Susan E; Newitt, John A; McKinnon, Murray; Trzaskos, James; Barrish, Joel C; Dodd, John H; Schieven, Gary L; Leftheris, Katerina

Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.

Lin, Shuqun; Wrobleski, Stephen T; Hynes, John; Pitt, Sidney; Zhang, Rosemary; Fan, Yi; Doweyko, Arthur M; Kish, Kevin F; Sack, John S; Malley, Mary F; Kiefer, Susan E; Newitt, John A; McKinnon, Murray; Trzaskos, James; Barrish, Joel C; Dodd, John H; Schieven, Gary L; Leftheris, Katerina.

Affiliation

Lin S; Department of Immunology Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.

Bioorg Med Chem Lett ; 20(19): 5864-8, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20732813

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Sulfur / Thiazoles / Mitogen-Activated Protein Kinase 14 / Protein Kinase Inhibitors / Nitrogen Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country:

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