Methodological considerations to understand the sensory function of TRP channels.
Curr Pharm Biotechnol
; 12(1): 3-11, 2011 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-20932263
ABSTRACT
Transient Receptor Potential channels are exquisite molecular transducers of multiple physical and chemical stimuli, hence the raising interest to study their relevance to Sensory Biology. Here we discuss a number of aspects of the biophysical and pharmacological properties of TRP channels, which we consider essential for a clear understanding of their sensory function in vivo. By examining concrete examples extracted from recent literature we illustrate that TRP channel research is a field in motion, and that many established dogmas on biophysical properties, drug specificity and physiological role are continuously reshaped, and sometimes even dismantled.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sensation
/
Transient Receptor Potential Channels
/
Drug Discovery
Limits:
Humans
Language:
En
Journal:
Curr Pharm Biotechnol
Journal subject:
BIOTECNOLOGIA
/
FARMACOLOGIA
Year:
2011
Document type:
Article
Affiliation country: