Delayed-type hypersensitivity reaction to piperacillin/tazobactam in a patient with an infected total knee replacement.
J Bone Joint Surg Br
; 92(11): 1596-9, 2010 Nov.
Article
in En
| MEDLINE
| ID: mdl-21037360
ABSTRACT
We describe a patient who developed a delayed-type hypersensitivity reaction to piperacillin/tazobactam in the cement beads and a spacer inserted at revision of total replacement of the left knee. We believe that this is the first report of such a problem. Our experience suggests that a delayed-type hypersensitivity reaction should be considered when a mixture of antibiotics such as piperacillin/tazobactam has been used in the bone cement, beads or spacer and the patient develops delayed symptoms of pain or painful paraesthesiae, fever, rash and abnormal laboratory findings in the absence of infection. The diagnosis was made when identical symptoms were induced by a provocation challenge test.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prosthesis-Related Infections
/
Arthroplasty, Replacement, Knee
/
Drug Hypersensitivity
/
Hypersensitivity, Delayed
/
Anti-Bacterial Agents
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
J Bone Joint Surg Br
Year:
2010
Document type:
Article
Affiliation country: