Structure-based vaccine design in HIV: blind men and the elephant?
Curr Pharm Des
; 16(33): 3744-53, 2010.
Article
in En
| MEDLINE
| ID: mdl-21128885
ABSTRACT
Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine design has great potential but, thus far, remains a largely unproven concept. Further structural information for the envelope (Env) glycoproteins, gp120 and gp41, is needed, particularly for understanding trimer-specific antibodies and their epitopes and to clarify atomic details of the structural elements responsible for masking crucial epitopes and for mediating the conformational rearrangements undertaken during the process of receptor-binding and membrane fusion.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Design
/
HIV Infections
/
HIV-1
/
AIDS Vaccines
/
Env Gene Products, Human Immunodeficiency Virus
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Pharm Des
Journal subject:
FARMACIA
Year:
2010
Document type:
Article
Affiliation country: