Canine specific ELISA for coagulation factor VII.
Vet J
; 190(3): 352-8, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-21216638
ABSTRACT
Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVIIC), but assays for measurement of canine specific FVII antigen (FVIIAg) have not been available to date. In this study, a canine specific ELISA for measurement of FVIIAg in plasma was developed and validated. The FVIIAg ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVIIC, the FVIIAg ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Dog Diseases
/
Factor VII Deficiency
/
Antigens
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Vet J
Journal subject:
MEDICINA VETERINARIA
Year:
2011
Document type:
Article
Affiliation country: