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Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Hutchinson, Douglas K; Flentge, Charles A; Donner, Pamela L; Wagner, Rolf; Maring, Clarence J; Kati, Warren M; Liu, Yaya; Masse, Sherie V; Middleton, Tim; Mo, Hongmei; Montgomery, Debra; Jiang, Wen W; Koev, Gennadiy; Beno, David W A; Stewart, Kent D; Stoll, Vincent S; Molla, Akhteruzzaman; Kempf, Dale J.
Affiliation
  • Hutchinson DK; Department of Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. hutsmi@sbcglobal.net
Bioorg Med Chem Lett ; 21(6): 1876-9, 2011 Mar 15.
Article in En | MEDLINE | ID: mdl-21316235
ABSTRACT
A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Benzothiadiazines / Viral Nonstructural Proteins Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Benzothiadiazines / Viral Nonstructural Proteins Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: