A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis.
Vaccine
; 29(15): 2803-9, 2011 Mar 24.
Article
in En
| MEDLINE
| ID: mdl-21320541
ABSTRACT
Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis
/
Viremia
/
Drug Carriers
/
Viral Vaccines
/
Adenoviridae
/
Chikungunya virus
/
Alphavirus Infections
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2011
Document type:
Article
Affiliation country: