Thrombus-free, human endothelial surface in the midregion of a Dacron vascular graft in the splanchnic venous circuit--observations after nine months of implantation.
J Vasc Surg
; 11(3): 468-75, 1990 Mar.
Article
in En
| MEDLINE
| ID: mdl-2138233
ABSTRACT
The addition of an endothelial cell lining to a prosthetic vascular graft may reduce the thrombogenicity of the blood-contacting surface. An endothelialized mesoatrial graft was implanted in a patient with Budd-Chiari syndrome caused by a primary inferior vena caval leiomyosarcoma. During the initial surgery a Dacron vascular graft was preclotted with plasma and then lined with microvascular endothelial cells derived from the patient's subcutaneous adipose tissue. The patient did well initially but 9 months later required resection of a mechanical stricture of the graft that occurred as it passed beneath the costochondral junction. Grossly, the luminal surface of the resected graft was free of thrombus, with a smooth, glistening, white surface. Light microscopy demonstrated a surface layer of cells morphologically consistent with an endothelial cell monolayer, a subendothelial layer composed of extracellular matrix and spindle-shaped cells, and granulation tissue around the Dacron fabric. Immunohistochemistry and electron microscopy confirmed the presence of vascular endothelium on the luminal surface. This report documents the successful achievement of a human endothelial cell monolayer that persisted for 9 months in the midportion of a Dacron vascular graft.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombosis
/
Blood Vessel Prosthesis
/
Endothelium, Vascular
/
Polyethylene Terephthalates
/
Graft Occlusion, Vascular
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Vasc Surg
Journal subject:
ANGIOLOGIA
Year:
1990
Document type:
Article